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Radioprotection and antitumor effects of mechanism on AHCC (Active Hexose Correlated Compound)
https://junshin.repo.nii.ac.jp/records/107
https://junshin.repo.nii.ac.jp/records/1070c7bc1d1-df54-4755-8325-d5d93b1a066b
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
純真学園大学雑誌-04号_p065-075 (1.6 MB)
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| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||||||||
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| 公開日 | 2017-06-29 | |||||||||||
| 言語 | ||||||||||||
| 言語 | eng | |||||||||||
| キーワード | ||||||||||||
| 言語 | en | |||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | Radiation protection | |||||||||||
| キーワード | ||||||||||||
| 言語 | en | |||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | anti-tumor effect | |||||||||||
| キーワード | ||||||||||||
| 言語 | en | |||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | SOD | |||||||||||
| キーワード | ||||||||||||
| 言語 | en | |||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | Lymphocyte | |||||||||||
| キーワード | ||||||||||||
| 言語 | en | |||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | AHCC | |||||||||||
| 資源タイプ | ||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||
| 資源タイプ | departmental bulletin paper | |||||||||||
| 著者 |
GU, Yeun-Hwa
× GU, Yeun-Hwa
× YAMASHITA, Takenori
× KANG, Ki-Mun
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| 抄録 | ||||||||||||
| 内容記述タイプ | Abstract | |||||||||||
| 内容記述 | Some natural products are able to inhibit radiation effects and exert an antitumor effect with fewer adverse reactions; however, their antitumor effects are less than those of widely-used synthetic drugs. AHCC (Active Hexose Correlated Compound) is a natural material that has been attracting attention, and we extracted this material with water and investigated the effect of continuous AHCC administration on radioactivity-induced reduction of hemocytes, in addition to the antioxidant and or effects of AHCC. Following a 1-week adjustment period, AHCC was administered intraperitoneally to male ICR mice at a dose of 250mg/kg every other day for 2weeks. Following administration, 2Gy whole-body irradiation was performed and the counts of leukocytes, lymphocytes, and granulocytes and monocytes in the peripheral blood were determined 1, 3, 7, 15 and 30days after irradiation. These cells were considered since they are closely associated with immunity to radioactivity. In a second experiment, AHCC was similarly administered to the mice for 2weeks after a 1-week adjustment period, and 2Gy whole-body irradiation was performed. The antioxidant effects in hemocytes were then investigated using 2,2'-azobis(2-amidinopropane) dihydrochloride (AAPH), a radical generator. In a third experiment, 1106 Sarcoma-180 cells were inoculated into the right thigh of mice, which were divided into four groups: control, AHCC-treated, 6Gy partial irradiated and AHCC-treated + 6Gy partial irradiated groups, and changes in tumor size were measured for 20days. Statistical analysis was conducted using ANOVA for multiple groups. In the three experiments, administration of AHCC inhibited the reduction of hemocytes caused by whole-body irradiation, showed antioxidant effects against radioactivity, and inhibited tumor growth, respectively. In conclusion, our data suggest that the antioxidant effect of AHCC inhibits hemocyte reduction caused by whole-body irradiation and enhances immunological inhibition of tumor growth. | |||||||||||
| 書誌情報 |
純真学園大学雑誌 en : Journal of Junshin Gakuen University, Faculty of Health Sciences 号 4, p. 65-75, 発行日 2015-03 |
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| 出版者 | ||||||||||||
| 出版者 | 純真学園大学 | |||||||||||
| ISSN | ||||||||||||
| 収録物識別子タイプ | ISSN | |||||||||||
| 収録物識別子 | 2186-6481 | |||||||||||
| 書誌レコードID | ||||||||||||
| 収録物識別子タイプ | NCID | |||||||||||
| 収録物識別子 | AA12581584 | |||||||||||
| 論文ID（NAID） | ||||||||||||
| 関連タイプ | isIdenticalTo | |||||||||||
| 識別子タイプ | NAID | |||||||||||
| 関連識別子 | 40020672042 | |||||||||||
| フォーマット | ||||||||||||
| 内容記述タイプ | Other | |||||||||||
| 内容記述 | application/pdf | |||||||||||
| 著者版フラグ | ||||||||||||
| 出版タイプ | VoR | |||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||
